In The Netherlands, DNA samples of persons from the national DNA database are kept, instead of being destroyed after standard DNA profiling as in some other countries. This is because the investigative use of the DNA samples from persons whose STR profile is stored in the national DNA database, involving additional DNA testing, is legally allowed.
Such sequencing can also be performed on a limited amount of DNA and can identify genomic changes that may be cryptic in other types of analyses. 2 These features of whole-genome sequencing

Some of these limitations are: (1) the tendency of various reverse transcriptases (RT) to generate spurious second-strand cDNA due to their DNA-dependent DNA polymerase activities 9,10,18; (2) the

DNA was first described by Watson and Crick in 1953, as double-stranded molecule that adopts a helical arrange-ment. Each individual’s genome contains a large amount of DNA that is a potential target for DNA profiling. DNA Structure DNA is often described as the “blue print of life,” because it

Forensic DNA analysis has vastly evolved since the first forensic samples were evaluated by restriction fragment length polymorphism (RFLP). Methodologies advanced from gel electrophoresis techniques to capillary electrophoresis and now to next generation sequencing (NGS). Capillary electrophoresis was and still is the standard method used in forensic analysis. However, dependent upon the
In the future, improved sequencing capabilities will allow the profiling of a large number of DNA-binding proteins, as well as a more complete set of chromatin marks in a myriad of epigenomes
This review contains a brief description of first, second, and third generation sequencing techniques, and focuses on the recent developments in human DNA analysis applicable in the forensic field. Relevance to the forensic analysis is that besides generation of standard STR-profiles, DNA repeats can also be sequenced to look for polymorphisms.
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    • dna sequencing vs dna profiling